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PUBLICATIONS

2024

  • Focusing on the tetra-partite synapse in Parkinson’s disease research using human patient-derived neurons. Diogo Cordeiro, Tchelet Stern, Shani Stern. Neural Regeneration Research, 2024.

 

2023

  • NGLY1 mutations cause protein aggregation in human neurons. Manole A, Wong T, Rhee A, Novak S, Tsimring K, Paucar A, Williams A, Traci Newmeyer T, Chin S, Schafer S, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo A, Andrade L, Manor U, Lee K, Stern S, Marchetto C, Gage F. In press, Cell Reports.

  • Brain-targeted liposomes loaded with monoclonal antibodies reduce alpha-synuclein aggregation and improve behavioral symptoms of Parkinson’s disease. Mor Sela, Maria Poley, Patricia Mora-Raimundo, Shaked Kagan, Aviram Avital, Maya Kaduri, Gal Chen ,Omer Adir, Adi Rozencweig, Yfat Weiss, Ofir Sade, Yael Leichtmann-Bardoogo, Lilach Simchi, Shlomit Age-Mizrachi, Batia Bell, Yoel Yeretz-Peretz, Aviv Zaid Or, Ashwani Choudhary, Idan Rosh, Diogo Cordeiro, Stav Choen-Adiv, Yevgeny Berdichevsky, Anas Ode, Jeny Shklover, Janna Shainsky-Roitman, Joshua E. Schroeder, Dov Hershkovitz, Peleg Hasson, Avraham Ashkenazi, Shani Stern, Tal Laviv ,Ayal Ben-Zvi, Avi Avital6, Uri Ashery, Ben M. Maoz, Avi Schroeder. Advanced Materials, 2023.

  • Seeking Convergence and Divergence between Autism and Schizophrenia using genomic tools and patients' neurons. Eva Romanovsky, Ashwani Choudhary, Ahmad Abu Akel, Shani Stern. BioRxiv, 2023.

  • Gene panels for epilepsy suggest that previously defined variants of unknown significance may play an important role in epilepsy and certain variants may be pathogenic when occurring together. Yara Hussein, Hila Weisblum-Neuman, Bruria Ben-Zeev,  Shani Stern. MedRxiv. 2023.

  • Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients. Liron Mizrahi, Ashwani Choudhary, Polina Ofer, Gabriela Goldberg, Elena Milanesi, John Kelsoe, David Gurwitz, Martin Alda, Fred H. Gage, Shani Stern. Molecular Psychiatry. 2023.

  • Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutationsYara Hussein, Utkarsh Tripathi, Ashwani Choudhary, Ritu Nayak, David Peles, Idan Rosh, Tatiana Rabinski, Jose Djamus, Gad David Vatine, Ronen Spiegel, Tali Garin-Shkolnik, Shani Stern. Translational Psychiatry 2023.

  • The NO Answer for Autism Spectrum Disorder (Adv. Sci. 22/2023). Manish Kumar Tripathi, Shashank Kumar Ojha, Maryam Kartawy, Wajeha Hamoudi, Ashwani Choudhary, Shani Stern, Adi Aran, Haitham Amal. Advanced Science Cover, 2023.

  • The NO Answer for Autism Spectrum Disorder. Manish Kumar Tripathi, Shashank Kumar Ojha, Maryam Kartawy, Wajeha Hamoudi, Ashwani Choudhary, Shani Stern, Adi Aran, Haitham Amal. Advanced Science 2023.

  • Recent studies put a focus on the tetra-partite synapse in Parkinson’s disease research using human induced pluripotent stem cells. Diogo Cordeiro, Shani Stern. In press, Neural Regeneration Research (NRR).

  • Proteins and Transcriptional Dysregulation of the Brain Extracellular Matrix in Parkinson’s Disease: A Systematic Review. Wote Amelo Rike, Shani Stern. IJMS, 2023.

  • Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson’s disease sporadic patients and with GBA1 mutations. Idan Rosh, Utkarsh Tripathi, Yara Hussein, Wote Amelo Rike, Andreea Manole, Diogo Cordeiro, Henry Houlden, Jurgen Winkler, Fred Gage, Shani Stern. BioRxiv, 2023.

  • Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson’s disease: A systematic review. Wote Rike, Shani Stern. MedRxiv, 2023.

2022

  • Tyro3 Promotes the Maturation of Glutamatergic Synapses. Sheng Miao, Lawrence Fourgeaud, Patrick Burrola, 
    Shani Stern, Yuhan Zhang, Kaisa Happonen, Sammy Weiser Novak, Fred Gage, Greg Lemke. SSRN Electronic Journal, 2022.

  • Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations. Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Ashwani chowdhary, Jose Djamus, Andreea Manole, Henry Haulden, Fred H. Gage, Shani Stern. BioRxiv, 2022.

  • Information theory characteristics improve the prediction of lithium response in bipolar disorder patients using an SVM classifier. Utkarsh Tripathi, Liron Mizrahi, Martin Alda, Gregory Falkovich, Shani Stern. Bipolar Disorders, 2022.

  • Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence. Kumar Kolatt Chandran, Adonis Yiannakas, Haneen Kayyal, Randa Salalha, Federica Cruciani, Liron Mizrahi, Mohammd Khamaisy, Shani Stern, Kobi Rosenblum. eNeuro, 2022

  • Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview. Ashwani Choudhary, Ritu Nayak, David Peles, Liron Mizrahi, Shani Stern. Schizophrenia Research, 2022.

  • Generation and characterization of iPSC lines (UOHi001-A, UOHi002-A) From a patient with SHANK3 mutation and her healthy motherRitu Nayak, Idan Rosh, Tatiana Rabinski, Menachem Mendel Percia, Shani Stern. Stem Cell Research, 2022.

  • Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations. Yara Hussein, Utkarsh Tripathi, Ashwani Choudhary, Ritu Nayak, David Peles, Idan Rosh, Jose Djamus, Ronen Spiegel, Tali Garin-Shkolnik, Shani Stern. BioRxiv, 2022.

  • Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons. Mark van den Hurk, Shong Lau, Maria C. Marchetto, Jerome Mertens, Shani Stern, Olga Corti, Alexis Brice, Beate Winner, Jürgen Winkler, Fred H. Gage & Cedric Bardy. NPJ Parkinson’s disease, 2022.

  • Immunoglobulin genes expressed in lymphoblast cell lines discern and predict lithium response in bipolar disorder patients. Liron Mizrahi, Ashwani Choudhary, Polina Ofer, Gabriela Goldberg, Elena Milanesi, John Kelsoe, David Gurwitz, Martin Alda, Fred Gage, Shani Stern. ResearchSquare, 2022.

  • Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence. Kumar Kolatt Chandran, Adonis Yiannakas, Haneen Kayyal, Randa Salalha, Federica Cruciani, Liron Mizrahi, Mohammd Khamaisy, Shani Stern, Kobi Rosenblum. BioRxiv, 2022.

  • Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview. Ashwani Choudhary, Ritu Nayak, David Peles, Liron Mizrahi, Shani Stern. BioRxiv, 2022.

  • Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patients. Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menahem Percia, Ran Ben Ezer, Maxim N. Shokhirev, Fan Qiu, Simon Schafer, Abed Mansour, Tchelet Stern, Pola Ofer, Yam Stern, Ana Mendes Diniz, Lynne Randolph Moore, Ritu Nayak, Aidan Aicher, Amanda Rhee, Thomas L. Wong, Thao Nguyen, Sara B. Linker, Beate Winner, Beatriz C. Freitas, Eugenia Jones, Cedric Bardy, Alexis Brice, Juergen Winkler, Maria C. Marchetto, Fred H. Gage. NPJ Parkinson’s disease, 2022.

  • Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission. Shani Stern, Lei Zhang, Meiyan Wang, Rebecca Wright, Diogo Cordeiro, David Peles, Yuqing Hang, Ana P. D. Mendes, Tithi Baul, Julien Roth, Shashank Coorapati, Marco Boks, Hilleke Hulshoff Pol, Kristen J. Brennand, Janos M Réthelyi, René S. Kahn, Maria C. Marchetto, Fred H. Gage. BioRxiv, 2022.

  • Information theory characteristics improve the prediction of lithium response in bipolar disorder patients using an SVM classifier. Utkarsh Tripathi, Liron Mizrahi, Martin Alda, Gregory Falkovich, Shani Stern. BioRxiv, 2022.

  • Generation and characterization of iPSC lines (UOHi001-A, UOHi002-A) From a patient with SHANK3 mutation and her healthy motherRitu Nayak, Idan Rosh, Tatiana Rabinski, Menachem Mendel Percia, Shani Stern. BioRxiv, 2022.

  • Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patients. Shani Stern, Shong Lau , Andreea Manole , Idan Rosh , Menahem Percia , Ran Ben Ezer , Maxim N. Shokhirev , Fan Qiu , Simon Schafer , Abed Mansour , Tchelet Stern, Pola Ofer , Yam Stern , Ana Mendes Diniz , Lynne Randolph Moore , Ritu Nayak , Aidan Aicher1 , Amanda Rhee , Thomas L. Wong , Thao Nguyen , Sara B. Linker , Beate Winner , Beatriz C. Freitas , Eugenia Jones , Cedric Bardy , Alexis Brice , Juergen Winkler , Maria C. Marchetto, Fred H. Gage. BioRxiv, 2022.

2021

  • Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes. IIrina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I Aqeilan, EMBO Molecular Medicine, 2021.

  • IQSEC2 Mutation Associated with Epilepsy, Intellectual Disability and Autism Results in Hyperexcitability of Patient Derived Neurons and Deficient Synaptic transmission. Boris Brant*, Tchelet Stern*, Huda Adwan Shekhidem*, Liron Mizrahi, Idan Rosh, Yam Stern, Polina Ofer, Ayat Asleh, George K. Essien Umanah, Reem Jada, Nina S. Levy, Andrew P. Levy, Shani Stern, Molecular Psychiatr2021.

  • Modeling genetic epileptic encephalopathies using brain organoids. Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab,Ehud Banne,Muhammad Mahajnah,Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan. EMBO Molecular Medicine 2021.

  • Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes Srinivasarao Repudi, Irina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I. Aqeilan, BioRxiv 2021

  • Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer patients. Jerome Mertens; Joseph R. Herdy; Larissa Traxler; Simon T. Schafer; Johannes C.M. Schlachetzki; Lena Böhnke; Dylan Reid; Hyungjun Lee; Dina Zangwill; Diana P. Fernandes; Ravi K. Agarwal; Raffaella Lucciola; Lucia Zhou-Yang; Lukas Karbacher; Frank Edenhofer; Shani Stern; Steve Horvath; Apua C. M. Paquola; Christopher K. Glass; Shauna Yuan; Lawrence S.B. Goldstein; Douglas Galasko; Fred H. Gage. Cell Stem Cell, 2021.

  • Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Renata Santos*, Sara Linker*, Shani Stern*, Ana Mendes, Maxim Shokhirev, Galina Erikson, Lynne Randolph-Moore, Vipula Racha, Yeni Kim, John Kelsoe, Anne Bang, Martin Alda, Maria Marchetto, Fred H. Gage.  (* equally contributed). Molecular Psychiatry, 2021.

  • Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population. Liron Mizrahi, Shani Stern. Open Biology, the Royal Society, 2021.

2020

  • Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. T.. Figueiredo, A.P.D. Mendes, G.S. Kobayashi, D.P. Moreira, D. Oliviera, E. Goulart, S. Stern, F. Kok, M.C. Marchetto, R. Santos, F.H. Gage, M. Zatz. Molecular Psychiatry, 2020.
     

  • Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population. Liron Mizrahi, Shani Stern. MedRxiv, 2020.​

  • A physiological instability displayed in hippocampal neurons derived from lithium non-responsive bipolar disorder patients. Shani Stern, Anindita Sarkar, Dekel Galor, Tchelet Stern, Arianna Mei, Yam Stern, Ana P. D. Mendes, Lynne Randolph-Moore, Guy Rouleau, Anne Bang, Renata Santos, Martin Alda, Maria C. Marchetto, Fred H. Gage. Biological Psychiatry, 2020.

  • Mechanisms underlying the hyperexcitability of CA3 and dentate gyrus hippocampal neurons derived from bipolar disorder patients. Shani Stern, Anindita Sarkar, Tchelet Stern, Arianna Mei, Ana P. D. Mendes, Yam Stern, Gabriela Goldberg, Dekel Galor, Thao Nguyen, Lynne Randolph-Moore, Yongsung Kim, Guy Rouleau, Anne Bang, Martin Alda, Renata Santos, Maria C. Marchetto, Fred H. Gage. Biological Psychiatry, 2020.

2019

                

  • An epilepsy-associated KCNT1 mutation enhances excitability of human iPSC-derived neurons by increasing Slack KNa currents. Imran H. Quraishi*, Shani Stern*, Kile Mangan*, Yalan Zhang, Syed R. Ali, Michael R. Mercier, Maria C. Marchetto, Michael J.. McLachlan, Eugenia M. Jones, Fred H. Gage and Leonard K. Kaczmarek. The Journal of Neuroscience 2019. (* equally contributed)

 

  • Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Simon T. Schafer, Apua C. M. Paquola, Shani Stern, David Gosselin, Manching Ku, Monique Pena, Thomas J. M. Kuret, Marvin Liyanage, Abed AlFatah Mansour, Baptiste N. Jaeger, Maria C. Marchetto, Christopher K. Glass, Jerome Mertens & Fred H. Gage. Nature Neuroscience 2019.

2018

 

  • Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Anindita Sarkar, Arianna Mei, Apua Paquola, Shani Stern, Cedric Bardy, Jason Klug, Stacy Kim, Neda Neshat,  Hyung Joon Kim, Manching Ku, Maxim N. Shokhirev, David Adamowicz, Maria Carolina Marchetto, Roberto Jappeli, Jennifer A. Erwin, Krishnan Padmanabhan, Matthew Shtrahman, Xin Jin,  Fred H. Gage. Cell Stem Cell 2018; https://doi.org/10.1016/j.stem.2018.04.009.

 

  • Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. S Stern*, R Santos*, MC Marchetto, APD Mendes ,GA Rouleau ,S Biesmans , Q-W Wang, J Yao, P Charnay, AG Bang, M Alda and FH Gage. Molecular Psychiatry 2018; doi: 10.1038/mp.2016.260. (* equally contributed) (Appeared on the June 2018 cover).

 

  • Potassium channel regulators are differentially expressed in hippocampi of Ts65Dn and Tc1 Down syndrome mouse models. Shani Stern, Rinat Keren and Elisha Moses. BioRxiv 2018.

 

  • Prediction of response to drug therapy in psychiatric disorders. Shani Stern, Sara Linker, Krishna C. Vadodaria, Maria C. Marchetto, Fred H. Gage. Open Biology, the Royal Society (2018).

2017

 

  • Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Vadodaria, K. C., Stern, S., Marchetto, M. C. and Gage, F. H. (2017) Cell and Tissue Research.

 

  • External excitation of neurons using electric and magnetic fields in one- and two- dimensional cultures. Shani Stern, Assaf Rotem, Yuri Burnishev, Eyal Weinreb and Elisha Moses. JoVE 2017. 

2016

 

  • Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers. Stern S, Biron D, Moses E. 2016. BMC Genetics 17(1):105.

2015

 

  • Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice. Stern, Shani, Menahem Segal and Elisha Moses (2015). EBioMedicine, Volume 2, Issue 9, 1048 – 1062. 

 

  • Chronaxie Measurements in Patterned Neuronal Cultures from Rat Hippocampus. Stern S, Agudelo-Toro A, Rotem A, Moses E, Neef A (2015) PLoS ONE 10(7): e0132577. doi:10.1371/journal.pone.0132577

2014

 

 

Book chapters

 

  • E. Moses and S. Stern, “Design of logical devices with neuronal cultures”, in Control motor y cognicion, propiedades emergentes de redes neuronales edited by Ranulfo Romo Pablo Rudomin, El Colegio Nacional Mexico City 2012.

Patents

  • (WO/2008/005702) APPARATUS AND METHOD FOR PROCESSING AN AUDIO SIGNAL. Inventors: Shani Stern, Itzhak Avayu.

 

  • (WO 2007/040883) VOICE ACTIVITY DETECTOR. Inventors: Shani Stern, Itzhak Avayu, Lev Levshits.

 

  • (WO/2007/030190) VOICE ACTIVITY DETECTOR AND METHOD OF OPERATION THEREIN. Inventors: Shani Stern, Izak Avayu, Uzi Cohen.

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