• Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patients. Shani Stern, Shong Lau , Andreea Manole , Idan Rosh , Menahem Percia , Ran Ben Ezer , Maxim N. Shokhirev , Fan Qiu , Simon Schafer , Abed Mansour , Tchelet Stern, Pola Ofer , Yam Stern , Ana Mendes Diniz , Lynne Randolph Moore , Ritu Nayak , Aidan Aicher1 , Amanda Rhee , Thomas L. Wong , Thao Nguyen , Sara B. Linker , Beate Winner , Beatriz C. Freitas , Eugenia Jones , Cedric Bardy , Alexis Brice , Juergen Winkler , Maria C. Marchetto, Fred H. Gage. BioRxiv, 2022.

  • Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes. IIrina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I Aqeilan, EMBO Molecular Medicine, 2021.

  • IQSEC2 Mutation Associated with Epilepsy, Intellectual Disability and Autism Results in Hyperexcitability of Patient Derived Neurons and Deficient Synaptic transmission. Boris Brant*, Tchelet Stern*, Huda Adwan Shekhidem*, Liron Mizrahi, Idan Rosh, Yam Stern, Polina Ofer, Ayat Asleh, George K. Essien Umanah, Reem Jada, Nina S. Levy, Andrew P. Levy, Shani Stern, Molecular Psychiatr2021.

  • Modeling genetic epileptic encephalopathies using brain organoids. Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab,Ehud Banne,Muhammad Mahajnah,Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan. EMBO Molecular Medicine 2021.

  • Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes Srinivasarao Repudi, Irina Kustanovich, Sara Abu-Swai, Shani Stern, Rami I. Aqeilan, BioRxiv 2021

  • Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer patients. Jerome Mertens; Joseph R. Herdy; Larissa Traxler; Simon T. Schafer; Johannes C.M. Schlachetzki; Lena Böhnke; Dylan Reid; Hyungjun Lee; Dina Zangwill; Diana P. Fernandes; Ravi K. Agarwal; Raffaella Lucciola; Lucia Zhou-Yang; Lukas Karbacher; Frank Edenhofer; Shani Stern; Steve Horvath; Apua C. M. Paquola; Christopher K. Glass; Shauna Yuan; Lawrence S.B. Goldstein; Douglas Galasko; Fred H. Gage. Cell Stem Cell, 2021.

  • Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Renata Santos*, Sara Linker*, Shani Stern*, Ana Mendes, Maxim Shokhirev, Galina Erikson, Lynne Randolph-Moore, Vipula Racha, Yeni Kim, John Kelsoe, Anne Bang, Martin Alda, Maria Marchetto, Fred H. Gage.  (* equally contributed). Molecular Psychiatry, 2021.

  • Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population. Liron Mizrahi, Shani Stern. Open Biology, the Royal Society, 2021.

  • Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. T.. Figueiredo, A.P.D. Mendes, G.S. Kobayashi, D.P. Moreira, D. Oliviera, E. Goulart, S. Stern, F. Kok, M.C. Marchetto, R. Santos, F.H. Gage, M. Zatz. Molecular Psychiatry, 2020.

  • Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population. Liron Mizrahi, Shani Stern. MedRxiv, 2020.​

  • A physiological instability displayed in hippocampal neurons derived from lithium non-responsive bipolar disorder patients. Shani Stern, Anindita Sarkar, Dekel Galor, Tchelet Stern, Arianna Mei, Yam Stern, Ana P. D. Mendes, Lynne Randolph-Moore, Guy Rouleau, Anne Bang, Renata Santos, Martin Alda, Maria C. Marchetto, Fred H. Gage. Biological Psychiatry, 2020.

  • Mechanisms underlying the hyperexcitability of CA3 and dentate gyrus hippocampal neurons derived from bipolar disorder patients. Shani Stern, Anindita Sarkar, Tchelet Stern, Arianna Mei, Ana P. D. Mendes, Yam Stern, Gabriela Goldberg, Dekel Galor, Thao Nguyen, Lynne Randolph-Moore, Yongsung Kim, Guy Rouleau, Anne Bang, Martin Alda, Renata Santos, Maria C. Marchetto, Fred H. Gage. Biological Psychiatry, 2020.


  • An epilepsy-associated KCNT1 mutation enhances excitability of human iPSC-derived neurons by increasing Slack KNa currents. Imran H. Quraishi*, Shani Stern*, Kile Mangan*, Yalan Zhang, Syed R. Ali, Michael R. Mercier, Maria C. Marchetto, Michael J.. McLachlan, Eugenia M. Jones, Fred H. Gage and Leonard K. Kaczmarek. The Journal of Neuroscience 2019. (* equally contributed)


  • Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Simon T. Schafer, Apua C. M. Paquola, Shani Stern, David Gosselin, Manching Ku, Monique Pena, Thomas J. M. Kuret, Marvin Liyanage, Abed AlFatah Mansour, Baptiste N. Jaeger, Maria C. Marchetto, Christopher K. Glass, Jerome Mertens & Fred H. Gage. Nature Neuroscience 2019.


  • Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Anindita Sarkar, Arianna Mei, Apua Paquola, Shani Stern, Cedric Bardy, Jason Klug, Stacy Kim, Neda Neshat,  Hyung Joon Kim, Manching Ku, Maxim N. Shokhirev, David Adamowicz, Maria Carolina Marchetto, Roberto Jappeli, Jennifer A. Erwin, Krishnan Padmanabhan, Matthew Shtrahman, Xin Jin,  Fred H. Gage. Cell Stem Cell 2018;


  • Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium. S Stern*, R Santos*, MC Marchetto, APD Mendes ,GA Rouleau ,S Biesmans , Q-W Wang, J Yao, P Charnay, AG Bang, M Alda and FH Gage. Molecular Psychiatry 2018; doi: 10.1038/mp.2016.260. (* equally contributed) (Appeared on the June 2018 cover).


  • Potassium channel regulators are differentially expressed in hippocampi of Ts65Dn and Tc1 Down syndrome mouse models. Shani Stern, Rinat Keren and Elisha Moses. BioRxiv 2018.


  • Prediction of response to drug therapy in psychiatric disorders. Shani Stern, Sara Linker, Krishna C. Vadodaria, Maria C. Marchetto, Fred H. Gage. Open Biology, the Royal Society (2018).


  • Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Vadodaria, K. C., Stern, S., Marchetto, M. C. and Gage, F. H. (2017) Cell and Tissue Research.


  • External excitation of neurons using electric and magnetic fields in one- and two- dimensional cultures. Shani Stern, Assaf Rotem, Yuri Burnishev, Eyal Weinreb and Elisha Moses. JoVE 2017. 


  • Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers. Stern S, Biron D, Moses E. 2016. BMC Genetics 17(1):105.


  • Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice. Stern, Shani, Menahem Segal and Elisha Moses (2015). EBioMedicine, Volume 2, Issue 9, 1048 – 1062. 


  • Chronaxie Measurements in Patterned Neuronal Cultures from Rat Hippocampus. Stern S, Agudelo-Toro A, Rotem A, Moses E, Neef A (2015) PLoS ONE 10(7): e0132577. doi:10.1371/journal.pone.0132577



Book chapters


  • E. Moses and S. Stern, “Design of logical devices with neuronal cultures”, in Control motor y cognicion, propiedades emergentes de redes neuronales edited by Ranulfo Romo Pablo Rudomin, El Colegio Nacional Mexico City 2012.


  • (WO/2008/005702) APPARATUS AND METHOD FOR PROCESSING AN AUDIO SIGNAL. Inventors: Shani Stern, Itzhak Avayu.


  • (WO 2007/040883) VOICE ACTIVITY DETECTOR. Inventors: Shani Stern, Itzhak Avayu, Lev Levshits.


  • (WO/2007/030190) VOICE ACTIVITY DETECTOR AND METHOD OF OPERATION THEREIN. Inventors: Shani Stern, Izak Avayu, Uzi Cohen.